HPAPI & Payload Synthesis

By November 2, 2018 Chemistry

HPAPI & Payload Synthesis

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HPAPI & Payload Synthesis

Zunachem has expertise in both chemical payloads and linkers that enables us to provide our customers with a broad range of linker-payload combinations and reagents for screening at Zunachem or elsewhere. Our payload resources include a toolbox of highly potent cytotoxic payloads (HPAPIs) with different mechanisms of action for use in the development of ADCs. Our new manufacturing facility in Bristol is capable of handling HPAPIs up to an OEL of 10ng/m3 (Zunachem Band 5).

  • Akt Inhibitors e.g. GDC-0068
  • DNA Transcription e.g. Dactinomycin
  • DNA cross-linking agents, such as Mitomycin C
  • Dihydrofolate Reductase (DHFR) Inhibitors such as Methotrexate
  • DNA Intercalators, including Doxorubicin HCL and Epirubicin HCL
  • Microtubule Inhibitors e.g Dolastatin-10 & Auristatins

In addition to our toolbox, Zunachem can design and synthesise custom combinations of potent cytotoxic payloads and linkers or provide guidance and advise on selection of payloads.

Zunachem can use its broad range of payloads in conjunction with its linker technologies to create a range of unique ADCs with different payloads, that can be screened by Zunachem, our customers or by third parties.  We can also provide linker, antibody and payload reagents to third party companies.

Working with Zunachem

Zunachem’s HPAPI and payload synthesis services are tailored to each project to ensure that the objectives are met or exceeded.

We collaborate with a wide range of organisations from virtual companies through to big pharma, including many of the world’s top companies, as well as academic research groups from across the globe.
To get more information, a quote or to schedule a teleconference please contact us.